Vyvanse Withdrawal: Symptoms, Timeline, and Detox Treatment

Vyvanse (lisdexamfetamine) is a central nervous system (CNS) stimulant often prescribed for children and adults with attention-deficit hyperactivity disorder (ADHD). It is also used to treat moderate to severe binge eating disorders and may occasionally be prescribed off-label for narcolepsy or related sleep concerns. As a Schedule II controlled substance, Vyvanse has recognized medical benefits but also carries a high risk of physical or psychological dependence. If dependence develops, discontinuing Vyvanse can bring on withdrawal, which can vary greatly from person to person. Withdrawal symptoms can affect daily functioning and mood, sometimes to the point of requiring professional intervention.

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How Is a Vyvanse “Crash” Different From Vyvanse Withdrawal

Some stimulants, especially those that act quickly (like methamphetamine), can cause what is known as a “crash” period marked by extreme tiredness and prolonged sleep after large doses. Vyvanse, being a long-acting stimulant, does not commonly cause these crash cycles. Instead, all stimulants — including Vyvanse — can lead to withdrawal if a high dose is suddenly discontinued, but the classic crash phenomenon is more commonly linked to short-acting stimulants.

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How To Avoid the Vyvanse Crash

Because Vyvanse is a long-acting medication, it naturally helps prevent the pronounced crash phases often associated with short-acting stimulants. Studies do not indicate that Vyvanse triggers the kind of crash typical of faster-acting stimulants. Therefore, minimizing crash risks is less of a concern with Vyvanse than with other stimulant drugs.

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What Is Vyvanse Withdrawal?

All stimulant medications can lead to withdrawal symptoms once the body and brain adapt to their presence. If Vyvanse is taken at higher doses and then abruptly stopped, the sudden drop in dopamine and norepinephrine can cause the brain to struggle to compensate. This mismatch is what spawns Vyvanse withdrawal symptoms.

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Vyvanse Withdrawal Symptoms

Withdrawal from Vyvanse can share traits with withdrawal from other stimulants. Common symptoms can include:

• Depression
• Agitation
• Disturbed sleep patterns
• Nightmares or vivid dreams
• Heightened appetite
• Slowed thinking
• Fatigue
• Physical discomfort

Higher Vyvanse doses or misuse can trigger more severe withdrawal effects, such as:

• Psychosis
• Paranoia
• Disorganized thoughts
• Hallucinations

Additionally, individuals using Vyvanse to treat ADHD or binge eating disorder may find their original symptoms returning once they stop the medication. Anyone experiencing a resurgence of these issues should consult their doctor.

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Vyvanse Withdrawal Timeline

The onset of withdrawal typically begins a few days after the final Vyvanse dose, with most symptoms easing within about two weeks. Not everyone who discontinues Vyvanse will experience withdrawal; as a result, there is no formal manufacturer protocol recommending dose tapering.

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How To Stop Taking Vyvanse

It’s important to involve your healthcare provider in any decision to stop taking Vyvanse. If you have been prescribed the drug for ADHD or binge eating disorder, stopping use could cause your prior symptoms to worsen or return. Your doctor can monitor and guide you if you choose to discontinue Vyvanse.

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Is It Okay to Quit Vyvanse Cold Turkey?

Since Vyvanse is long-acting, you might be able to discontinue it without tapering in certain circumstances. Vyvanse’s half-life (8.6 to 11.3 hours) means it typically takes several days for the drug to be fully metabolized. However, this doesn’t eliminate the possibility of withdrawal, especially if you’re on a high dose. In such cases, or if you have a history of withdrawal difficulties, your doctor might recommend gradually lowering the dosage to minimize risks.

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Tapering Off Vyvanse

A taper is when the dose is reduced progressively so the body can gradually adjust before cessation. While not always mandatory, this approach may be beneficial if you’ve been taking a dose above the recommended maximum of 70 mg per day. Although limited research exists on specific Vyvanse taper regimens, one study evaluated patients on extremely high doses (150 mg or more) by initially reducing the dose to 50 mg for a week and then stopping the drug completely.

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Vyvanse Medical Detox

Certain drugs can be managed with targeted medications during withdrawal, but no such medication is formally approved to address Vyvanse withdrawal. Instead, therapy and supportive treatments can help alleviate psychological withdrawal symptoms. Over-the-counter remedies may also be used to address issues like headaches or nausea. Attending a professional detox program ensures consistent support and oversight, making it easier to focus on recovery and handle any difficult withdrawal phases.

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How Long Does It Take To Detox From Vyvanse?

Withdrawal symptoms in those discontinuing Vyvanse often show up within a few days and tend to subside within about two weeks. Consequently, a Vyvanse-specific detox program may last from several days to a couple of weeks, depending on individual needs. At The Recovery Village Ridgefield, the average medical detox length for stimulant dependencies is often around five to ten days.

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Find a Detox Center Near You

If you or a loved one struggles with Vyvanse dependence, The Recovery Village Ridgefield is ready to help. Contact us to learn about our tailored treatment programs that address substance use disorders and co-occurring mental health issues. You deserve the chance to pursue a healthier life — call today.