Oxycodone Withdrawal & Detox: Symptoms, Timeline & Treatment

Key Takeaways

• Oxycodone is a powerful opioid painkiller that can lead to dependence and withdrawal.
• Withdrawal symptoms can be intense, making relapse more likely without proper support.
• Symptoms may appear within 12 hours of the last dose, with psychological effects persisting for months.
• Medical detox can ease the withdrawal process and help individuals transition to long-term recovery.

What Is Oxycodone?

Oxycodone is a prescription opioid used to manage moderate to severe pain, often when other treatments fail. Despite efforts to control its distribution, prescriptions peaked in 2012, with a decline noted since then due to increased awareness of the opioid crisis. However, oxycodone remains widely prescribed, with over 142 million fills in 2020. Being a Schedule II controlled substance, oxycodone carries a high risk of addiction and dependence, which can lead to severe withdrawal symptoms if usage stops abruptly.

Oxycodone Withdrawal

Regular use of oxycodone can alter the brain’s chemistry, making the body dependent on the drug. Oxycodone influences neurotransmitters like dopamine and noradrenaline, which affect mood and anxiety responses. As the brain adjusts, reducing or stopping oxycodone intake leads to a deficiency in dopamine and an excess of noradrenaline, resulting in withdrawal symptoms such as anxiety, depression, nausea, and physical discomfort. Medical supervision during withdrawal can manage these symptoms and prevent dangerous complications.

Can Oxycodone Withdrawal Be Fatal?

While withdrawal is usually uncomfortable rather than life-threatening, severe cases can pose serious risks, particularly due to dehydration from vomiting and diarrhea. This can lead to electrolyte imbalances, which may cause seizures, kidney failure, or even death. Medical detox helps mitigate these risks, making the withdrawal process safer.

Duration of Oxycodone Withdrawal

The acute physical symptoms of oxycodone withdrawal typically last between four to seven days. However, the psychological aspects can persist much longer, sometimes for weeks, months, or even years. This extended period, known as Post-Acute Withdrawal Syndrome (PAWS), includes symptoms like anxiety, depression, and an inability to feel pleasure (anhedonia). Consistent support is crucial for managing these lingering effects.

Oxycodone Withdrawal Timeline

Withdrawal from oxycodone generally follows a standard pattern for short-acting opioids:

• 12 Hours: Initial physical and psychological symptoms begin.
• 36–72 Hours: Physical symptoms peak, including muscle aches, nausea, and tremors.
• 4–7 Days: Physical symptoms gradually subside.
• Weeks to Months: Psychological symptoms may continue, requiring ongoing support.

Factors Influencing Withdrawal

Several factors affect how long withdrawal symptoms last, including:

• Duration and intensity of oxycodone use.
• Type of oxycodone (e.g., extended-release vs. immediate-release).
• Use of other substances or medications.
• Genetics, age, and overall health.
• Mental health status and support systems.

Common Withdrawal Symptoms

Oxycodone withdrawal symptoms fall into two main categories:

• Physical Symptoms: Muscle pain, stomach cramps, diarrhea, rapid heartbeat, sweating, chills, and tremors.
• Psychological Symptoms: Anxiety, insomnia, irritability, depression, and increased sensitivity to stress.

Coping with Withdrawal

Managing withdrawal involves more than just addressing physical symptoms. Here are some strategies to consider:

• Engage in light physical activity like walking.
• Stay hydrated, especially if experiencing vomiting or diarrhea.
• Eat nutritious, whole foods to support recovery.
• Join a support group to stay connected with others in recovery.
• Practice mindfulness and meditation to manage anxiety.

Detox Options for Oxycodone Withdrawal

Detoxing from oxycodone can be challenging, but there are several options to consider:

Medical Detox

• Inpatient medical detox provides 24/7 care, with medication-assisted treatment to reduce withdrawal symptoms.
• Dose tapering is often used to ease the transition off oxycodone.

Outpatient Detox

• Outpatient detox allows patients to remain at home while attending regular medical check-ins.
• Best suited for those with mild dependence and strong social support.

At-Home Detox

• Detoxing at home is generally not recommended due to the risk of complications.
• If attempted, gradual tapering and strong support from friends or family are essential.

Cold Turkey Approach

• Abruptly stopping oxycodone can lead to severe withdrawal symptoms and is not advised.
• Tapering under medical supervision reduces the risk of relapse.

Finding the Right Detox Center

Choosing the right detox program is vital for recovery. Consider factors such as:

• Cost: Explore options for insurance coverage, sliding scale payments, and financial aid programs.
• Accreditation: Look for centers accredited by The Joint Commission or CARF.
• Staff-to-Patient Ratio: A lower ratio often means more personalized care.
• Treatment Options: Flexibility and individualized care are key to successful recovery.
• Location: Consider whether proximity to home or distance from triggering environments is more beneficial.

Medications Used in Detox

Medication-assisted treatment is common in managing opioid withdrawal, with options like:

• Suboxone: Combines buprenorphine and naloxone to reduce cravings.
• Methadone: Provides long-term opioid relief without the high.
• Clonidine: Eases withdrawal symptoms like anxiety and agitation without the use of opioids.

Oxycodone Detox at The Recovery Village Indianapolis

Taking the step to stop oxycodone use can be daunting, but you don’t have to do it alone. The Recovery Village Indianapolis offers comprehensive support, from medical detox to ongoing therapy. Our multidisciplinary team creates personalized treatment plans, ensuring both physical and mental health needs are met. If you or a loved one is struggling with oxycodone dependence, contact us today to start your journey to recovery.